BENG 221 Mathematical Methods in Bioengineering
Fall 2018
START OF CLASSES
- September 27: Lecture 1
[Slides]
[Notes]
Introduction. Ordinary differential equations (ODEs), and initial and
boundary conditions. Solution of homogeneous and inhomogeneous ODEs.
- September 28: Lecture 2, tutorial and problem solving session
[Notes]
[Laplace
tables and more]
Introduction to Matlab for linear systems. Laplace and Fourier
transforms. Linear time-invariant systems, impulse response, and
transfer function.
WEEK 1
- October 2: Lecture 3
[Notes]
Eigenvalue and eigenvector analysis, and multimode analysis.
Principal component analysis and singular value decomposition.
- October 4: Lecture 4
[Slides]
[Notes]
[Matlab code]
Analytical and numerical techniques for solving ODEs. Introduction to
Matlab for ODEs.
- October 5: Problem solving session--student presentations
[Reports]
Solution to example problems, using paper and pencil, and verified by
numerical simulation.
WEEK 2
- October 9: Lecture 5
[Notes]
[Matlab code]
Introduction to PDEs. One-dimensional heat equation, and its equivalents in
electrical and chemical transport with applications to biomedical engineering.
Flux through membranes. One-dimensional wave equation in an electrical
transmission line, with open and short circuit termination. Finite difference
PDE approximations.
- October 11: Lecture 6
[Notes]
[Fourier tables]
[Matlab code]
Solutions to PDEs over bounded and unbounded domains. Separation of
variables. Boundary value problem and solution of the x dependent equation.
Product solution of the PDEs with specified boundary conditions, and Fourier
series expansions of initial conditions. Solutions over infinite domains using
Fourier transforms.
- October 12: Problem solving session--student presentations
[Reports]
WEEK 3
- October 16: Lecture 7
[Notes]
Heat equation. Temperature, thermal energy, and flux. Diffusion of thermal
energy, and boundary conditions on temperature and flux. Thermal equilibrium.
- October 18: Lecture 8
[Notes]
Analytical solution to the inhomogeneous heat equation with space varying
source and boundary conditions. Decomposition of the solution into a
particular steady-state solution, and Fourier series eigenmodes of the
homogeneous solution. Fourier series expansions of initial conditions
revisited.
- October 19: Problem solving session--student presentations
[Reports]
WEEK 4
- October 23: Lecture 9
[Notes]
[Green's blues]
Analytical solution to inhomogeneous PDEs using Green's functions.
Relationship to impulse response of linear time and space invariant systems.
Green's solution to the inhomogeneous heat equation with time-varying
and space-varying heat source.
- October 25: Lecture 10
[Notes]
[Green's examples]
Extended Green's solution to the inhomogeneous heat equation with time-varying
value and flux boundary conditions. Solutions on infinite domains using
Laplace and Fourier transforms.
- October 26: Problem solving session--student presentations
[Reports]
WEEK 5
- October 30: Lecture 11
[Notes]
Heat and diffusion equation in space and time. Separation of variables for
cartesian separable boundary conditions. Bounded, infinite, and semi-infinite
domains.
- November 1: Lecture 12
[Notes]
[Practice midterm]
[Solutions]
[Laplace tables]
[Fourier tables]
Review and practice midterm.
- November 2: Problem solving session--student presentations
[Reports]
WEEK 6
- November 6: Midterm
[Midterm]
- November 8: Lecture 13
[Notes]
Review of vector calculus. Gradients, divergence, curl, and Laplacian.
Transformation between Cartesian, cylindrical, and radial coordinates. Fields
and potentials. Divergence theorem, and Stokes theorem.
- November 9: Problem solving session--student presentations
[Reports]
WEEK 7
- November 13: Lecture 14
[Notes]
[Matlab code]
Diffusion in polar and cylindrical coordinates. Analytical solution
using Bessel functions. Value and flux boundary conditions in terms of
roots and extrema of Bessel functions. Fourier-Bessel series
expansian of initial conditions.
- November 15: Lecture 15
[Notes]
Gradient descent optimization. First-order and higher-order methods for
null-finding and function minimization. Introduction to linear and nonlinear
control systems in bioengineering.
- November 16: Problem solving session--student presentations
[Reports]
WEEK 8
- November 20: Lecture 16
[Notes]
[Matlab code]
[FEniCS platform]
Numerical solution to PDEs using finite element methods. Orthogonal,
non-orthogonal, and triangular elements. Practical applications in
bioengineering.
- November 22-23: Thanksgiving
WEEK 9
- November 27: Lecture 17
[Notes]
Electrostatics. Coulomb's law. Electric field and potential. Work and moving
charge. Equivalence of surface/field product and enclosed charge. Gauss's
law, and Poisson's and Laplace's equation. Electric field near and in
conductors. Dielectric phenomena. Capacitance.
- November 29: Lecture 18
[Notes]
[Supplement]
Introduction to electromagnetism using Maxwell's equations. Wave propagation
in homogeneous and inhomogeneous media. Far and near field. RF telemetry and
power delivery. Tissue absorption.
- November 30: Problem solving session--student presentations
[Reports]
WEEK 10
- December 4: Lecture 19
[Notes]
The one dimensional wave equation. The vibrating string as a boundary value
problem. Vibrating string clamped at both ends. Standing waves and summation
of traveling waves. Sound and transmission of waves in gases.
- December 6: Lecture 20
[Notes]
- December 7: Problem solving session--student presentations
[Reports]
FINALS WEEK
- December 15: Final project reports due
-
Alfio Quarteroni, Riccardo Sacco, and Fausto Saleri, Numerical
Mathematics, Texts in Applied Mathematics 37, Springer, 2000 (2nd Ed., 2007).
-
Richard Haberman, Applied Partial Differential
Equations (4th Edition), Pearson-Prentice Hall, 2004.
-
Y.J. Shin and L. Bleris, "Linear
Control Theory for Gene Network Modeling," PLoS ONE, vol. 5
(9), e12785 (doi:10.1371/journal.pone.0012785). 2010.
-
H. M. Schey, Div, Grad, Curl, and All That: An Informal Text on Vector
Calculus (4th Edition), Norton Press, 2005.
-
Richard Fitzpatrick, Classical
Electromagnetism: An intermediate level course, Univ. Texas, 2006.
-
Albert Einstein, Investigations on the theory of the Brownian movement, Dover
Publications Inc., 1956 (translation from the 1905 original).
-
Wikipedia, the free encyclopedia:
-
Gerard Michon,
Final Answers
on Maxwell's Equations, Numericana, 2009.