Schedule and lecture notes:

WEEK 1

• Tuesday January 7: Lecture 1 [Notes]
  Introduction to the course and to bioinstrumentation. Instrumentation systems, and operational modes.
  Reading: Webster Ch. 1 (Sec. 1.2, 1.3, 1.5, 1.8, 1.9).
  
  
• Thursday January 9: Lecture 2 [Notes] [Bode Plot Guide]
  Measurement characteristics. Review of circuit analysis.
  Reading: Webster Ch. 1 (Sec. 1.9, 1.10).
  
  
• Friday January 10: Review 1 [Problems and Solutions]
  Exercises and practice homework.

WEEK 2

• Tuesday January 14: Lecture 3 [Notes]
  Displacement, strain, and pressure transducers. Potentiometers, voltage dividers, and Wheatstone bridges.
  Reading: Webster Ch. 2 (Sec. 2.1-2.4).
  
  
• Thursday January 16: Lecture 4 [Notes]
  Inductive, capacitive, and piezoelectric sensors. Thermocouples and thermistors. Switches and relays.
  Reading: Webster Ch. 2 (Sec. 2.5-2.9).
  
  
• Friday January 17: Review 2 [Practice Quiz and Solutions]
  Exercises and practice quiz.

WEEK 3

• Tuesday January 21: Lecture 5 [Notes] [Demos]
  Active circuit analysis and design. Power supplies. Operational amplifiers (op-amps). Active filtering, and impedance buffering.
  Reading: Webster Ch. 3 (Sec. 3.1-3.4, 3.10, 3.11, 3.12, 3.14).
  
  
• Thursday January 23: Lecture 6 [Notes] [Demos]
  Comparators, timers, and digital circuits.
  Reading: Webster Ch. 3 (Sec. 3.5, 3.16).
  
  
• Friday January 24: Quiz 1 [Study Guide] [Quiz] [Solutions]

WEEK 4

• Tuesday January 28: Lecture 7 [Notes]
  Origins of biopotentials. Excitable Cells. Nernst and resting potentials. Action Potentials.
  Reading: Webster Ch. 4 (Sec. 4.1, 4.2).
  
  
• Thursday January 30: Lecture 8 [Notes]
  Volume conduction and biopotentials. ECG, EEG, ENG, EMG, EOG, and ERG.
  Reading: Webster Ch. 4 (Sec. 4.2-4.8).
  
  
• Friday January 31: Review 3 [Problems and Solutions]
  Exercises and practice homework.

WEEK 5

• Tuesday February 4: Lecture 9 [Notes]
  Biopotential electrodes. Half cell potential and overpotential of the electrode-electrolyte interface. Polarizable and non-polarizable electrodes. Ag/AgCl electrode, and equivalent circuit model. Skin-electrode interface model.
  Reading: Webster Ch. 5 (Sec. 5.1-5.5).
  
  
• Thursday February 6: Lecture 10 [Notes]
  Examples of biopotential sources, recording and stimulation electrodes, and biosignal processing.
  Reading: Webster Ch. 5 (Sec. 5.6-5.11) and Ch. 4 (Sec. 4.4-4.8 review).
  
  
• Friday February 7: Review 4 [Practice Quiz and Solutions]
  Exercises and practice quiz.

WEEK 6

• Tuesday February 11: Lecture 11 [Notes]
  Biopotential amplifiers. The electrocardiogram revisited. Cardiac vector, and lead vectors. Frontal plane and transversal plane 12-lead electrocardiogram. Wilson's central terminal.
  Reading: Webster Ch. 6 (Sec. 6.1, 6.2) and Ch. 4 (Sec. 4.6 review).
  
  
• Thursday February 13: Lecture 12 [Notes]
  Biopotential amplifiers: problems and solutions. Interference and common-mode suppression. Electrode impedance matching. Driven right leg active grounding. Capacitive loading cancellation.
  Reading: Webster Ch. 6 (Sec. 6.3-6.6).
  
  
• Friday February 14: Quiz 2 [Study Guide] [Quiz] [Solutions]

WEEK 7

• Tuesday February 18: Lecture 13 [Notes]
  Blood pressure measurement.
  Reading: Webster Ch. 7 (Sec. 7.1-7.4, Sec. 7.13-7.14).
  
  
• Thursday February 20: Lecture 14 [Notes]
  Blood volume and flow measurement.
  Reading: Webster Ch. 8 (Sec. 8.1-8.4).
  
  
• Friday February 21: Review 5 [Problems and Solutions]
  Exercises and practice homework.

WEEK 8

• Tuesday February 25: Lecture 15 [Notes]
  Electrochemical biosensors for blood-gas and acid-base physiology. pH, PO2, and PCO2.
  Reading: Webster Ch. 10 (Sec. 10.1-10.2).
  
  
• Thursday February 27: Lecture 16 [Notes]
  Ion-selective and optical biosensors. Immunologically sensitive field-effect transistors, chemical fibrosensors, and non-invasive optical techniques.
  Reading: Webster Ch. 10 (Sec. 10.3-10.6).
  
  
• Friday February 28: Review 6 [Practice Quiz and Solutions]
  Exercises and practice quiz.

WEEK 9

• Tuesday March 4: Lecture 17 [Notes]
  Electrical safety. Physiological effects of electricity. Macroshock and microshock hazards.
  Reading: Webster Ch. 14 (Sec. 14.1-14.2).
  
  
• Thursday March 6: Lecture 18 [Notes]
  Electrical distribution and ground faults. Basic protection techniques against shock and equipment damage.
  Reading: Webster Ch. 14 (Sec. 14.3-14.9).
  
  
• Friday March 7: Quiz 3 [Study Guide] [Quiz] [Solutions]

WEEK 10

• Tuesday/Thursday March 11-13: Final project presentations

FINALS WEEK

• Tuesday March 18: Final project reports due
  
  

Reading and reference materials:

• Webster JG, Medical Instrumentation: Application and Design, 5th ed., John Wiley & Sons: New York, 2020.
• Thomas R.E., Rosa A.J. and Toussaint G.J., The Design and Analysis of Linear Circuits, 7th Ed., Wiley 2012 (MAE 140 textbook).
• Paul Falstad, Electronics Demonstrations and several other Java applets.
• Akinin A., Paul A., Wang J., Buccino A., and Cauwenberghs G., “Biopotential Measurements and Electrodes,” in Neural Engineering, B. He, Ed., Ch. 2, pp. 65-96, Springer Nature, 2020.
• Ha S., Kim C., Chi Y.M., Akinin A., Maier C., Ueno A. and Cauwenberghs G., "Integrated Circuits and Electrode Interfaces for Noninvasive Physiological Monitoring," IEEE Transactions on Biomedical Engineering, vol. 61 (5), pp. 1522-1537, 2014.
• Chi Y.M, Jung T.P. and Cauwenberghs G., "Dry-Contact and Noncontact Biopotential Electrodes: Methodological Review," IEEE Reviews in Biomedical Engineering, vol. 3, pp. 106-119, 2010.
• Dalziel CF, "Deleterious Effects of Electric Shock," Meeting of Experts on Electrical Accidents and Related Matters, International Labour Office, Geneva Switzerland, 1961.